The serotonin system in autism spectrum disorder: From biomarker to animal models

Highlights • Elevated whole-blood serotonin is a well-replicated biomarker found in 25% of children with autism spectrum disorder. • In addition to a well-defined role in adults, serotonin modulates neurodevelopment, including sensory development. • The serotonin transporter gene is associated with...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2016-05, Vol.321, p.24-41
Hauptverfasser:	Muller, C.L, Anacker, A.M.J, Veenstra-VanderWeele, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autism Spectrum Disorder - diagnosis Autism Spectrum Disorder - genetics Autism Spectrum Disorder - metabolism Biomarkers - metabolism Brain - metabolism Disease Models, Animal Female genetic Genetic Association Studies Genetic Linkage Humans Male Mice, Mutant Strains monoamine multisensory neurodevelopment Neurology platelet reuptake Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins - genetics Serotonin Plasma Membrane Transport Proteins - metabolism Sex Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Elevated whole-blood serotonin is a well-replicated biomarker found in 25% of children with autism spectrum disorder. • In addition to a well-defined role in adults, serotonin modulates neurodevelopment, including sensory development. • The serotonin transporter gene is associated with whole-blood serotonin levels and with autism risk but only in males. • A serotonin transporter knock-in mouse shows elevated blood serotonin levels and altered social and repetitive behavior. • The serotonin system is a prime candidate for treatment development in children with this heritable biomarker.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.11.010