Assessing Cell and Organ Senescence Biomarkers

A major goal in cancer and aging research is to discriminate the biochemical modifications that happen locally that could account for the healthiness or malignancy of tissues. Senescence is one general antiproliferative cellular process that acts as a strong barrier for cancer progression, playing a...

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Veröffentlicht in:	Circulation research 2012-06, Vol.111 (1), p.97-109
Hauptverfasser:	de Jesus, Bruno Bernardes, Blasco, Maria A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - metabolism Aging - pathology Animals Biological and medical sciences Biomarkers - metabolism Cellular Senescence - genetics Fundamental and applied biological sciences. Psychology Genetic Markers Genotype Humans Oncogenes Phenotype Telomere - metabolism Telomere Shortening Vertebrates: cardiovascular system
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Beschreibung
Zusammenfassung:	A major goal in cancer and aging research is to discriminate the biochemical modifications that happen locally that could account for the healthiness or malignancy of tissues. Senescence is one general antiproliferative cellular process that acts as a strong barrier for cancer progression, playing a crucial role in aging. Here, we focus on the current methods to assess cellular senescence, discriminating the advantages and disadvantages of several senescence biomarkers.
ISSN:	0009-7330 1524-4571
DOI:	10.1161/CIRCRESAHA.111.247866