Integrated Metabolomics Study of the Milk of Heat-stressed Lactating Dairy Cows

Heat stress (HS) damages the global dairy industry by reducing milk yields and quality, harming health, and damaging the reproduction of dairy cows, causing huge economic losses each year. However, an understanding of the physiological mechanism of HS lactating dairy cows remains elusive. Here, a me...

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Veröffentlicht in:	Scientific reports 2016-04, Vol.6 (1), p.24208-24208, Article 24208
Hauptverfasser:	Tian, He, Zheng, Nan, Wang, Weiyu, Cheng, Jianbo, Li, Songli, Zhang, Yangdong, Wang, Jiaqi
Format:	Artikel
Sprache:	eng
Schlagworte:	140/131 631/92/320 692/53/2421 Acetone Amino acids Animal lactation Animals Biomarkers Biomarkers - metabolism Blood C-Reactive Protein - chemistry Cattle Chromatography, Liquid Creatine Cytochromes c - chemistry Cytokines - chemistry Dairy cattle Dairy industry Female Heat stress Heat tolerance Hot Temperature Humanities and Social Sciences Intestinal microflora Lactation - physiology Lactic acid Least-Squares Analysis Lecithin Linoleic acid Lipid metabolism Lysophosphatidylcholine Magnetic Resonance Spectroscopy Metabolic pathways Metabolism Metabolites Metabolomics Metabolomics - methods Milk Milk - chemistry multidisciplinary NMR Nuclear magnetic resonance Oleic acid Phosphatidylcholine Pyruvic acid Science Science (multidisciplinary) Spectroscopy Stress, Physiological Tandem Mass Spectrometry Trimethylamine
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Zusammenfassung:	Heat stress (HS) damages the global dairy industry by reducing milk yields and quality, harming health, and damaging the reproduction of dairy cows, causing huge economic losses each year. However, an understanding of the physiological mechanism of HS lactating dairy cows remains elusive. Here, a metabolomics study using LC-MS and 1 H NMR spectroscopy was performed to analyze the metabolomic differences in the milk between HS-free and HS dairy cows, and discover diagnostic biomarkers and changes in the metabolic pathway. A total of 53 discriminating metabolites were significantly up- or down-regulated in the HS group compared with the HS-free group ( P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep24208