The entire spectrum of typical and atypical magnetic resonance imaging changes in a single case of Wilson's disease

On investigating the case, patient's MRI of the brain showed symmetrical hyperintensities in basal ganglia and thalamus and asymmetrical subcortical white matter hyperintensities on T2-weighted imaging sequence [Figure 1]a and [Figure 1]b. MRI was also remarkable in revealing classical changes in midbrain indicative of the "Face of giant panda" along with central pontine myelinolysis (CPM)-like changes in pons, appearing as a "Bisected pons" [Figure 1]c and [Figure 1]d. Considering MRI features and K-F ring suggestive of Wilson's disease, patient's further investigations were directed accordingly. [2] However, classical midbrain sign of "Face of giant panda," which is characterized by high T2-weighted signal intensity in tegmentum with relative preservation of red nucleus and lateral part of substantia nigra pars reticulata, is occasionally reported.