Influence of maternal thyroid hormones during gestation on fetal brain development

Influence of maternal thyroid hormones during gestation on fetal brain development

Highlights • Thyroid hormones (THs) are crucial for key maturational processes during early brain development. • Maternal TH deficiency during pregnancy may result in impaired offspring cognitive development. • Gestational conditions related to stress may modulate maternal thyroid function.

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Bibliographische Detailangaben
Veröffentlicht in:Neuroscience 2017-02, Vol.342, p.68-100
Hauptverfasser: Moog, N.K, Entringer, S, Heim, C, Wadhwa, P.D, Kathmann, N, Buss, C
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Brain - embryology
Brain - metabolism
brain development
Cognition - physiology
Female
fetal programing
HPT axis
Humans
Neurology
Pregnancy
Pregnancy Complications - metabolism
stress
thyroid hormones
Thyroid Hormones - deficiency
Thyroid Hormones - metabolism
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Beschreibung
Zusammenfassung:Highlights • Thyroid hormones (THs) are crucial for key maturational processes during early brain development. • Maternal TH deficiency during pregnancy may result in impaired offspring cognitive development. • Gestational conditions related to stress may modulate maternal thyroid function.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.09.070