Limited independent prognostic value of MMP-14 and MMP-2 expression in ovarian cancer

In cancer, various MMPs play a role in progression and metastasis and their overexpression generally indicates a poor prognosis. MMP-14 is the main activator of MMP-2 and both molecules play a role in normal ovarian follicular development. Earlier reports indicated a prognostic value for both MMP-14...

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Veröffentlicht in:	Diagnostic pathology 2016-04, Vol.11 (34), p.34-34, Article 34
Hauptverfasser:	Vos, M Caroline, van der Wurff, Anneke A M, Bulten, Johan, Kruitwagen, Roy, Feijen, Harrie, van Kuppevelt, Toin H, Hendriks, Thijs, Massuger, Leon F A G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Analysis Biomarkers, Tumor - analysis Care and treatment Complications and side effects Disease-Free Survival Epithelial Cells - enzymology Female Humans Immunohistochemistry Kaplan-Meier Estimate Matrix Metalloproteinase 14 - analysis Matrix Metalloproteinase 2 - analysis Metastasis Middle Aged Multivariate Analysis Neoplasm Staging Netherlands Ovarian cancer Ovarian Neoplasms - enzymology Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Proportional Hazards Models Retrospective Studies Risk Factors Stromal Cells - enzymology Time Factors Treatment Outcome
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Zusammenfassung:	In cancer, various MMPs play a role in progression and metastasis and their overexpression generally indicates a poor prognosis. MMP-14 is the main activator of MMP-2 and both molecules play a role in normal ovarian follicular development. Earlier reports indicated a prognostic value for both MMP-14 and MMP-2 in ovarian cancer. This study was designed to determine the prognostic value of MMP-14 and MMP-2 expression in ovarian cancer with data on long-term follow-up. Tumor samples of 94 consecutive ovarian cancer patients from one regional laboratory were evaluated. Clinical and survival data were collected and related to known prognostic factors, as well as to the expression of MMP-14 and MMP-2 as determined by semi-quantitative immunohistochemistry. Epithelial MMP-14 expression correlated with stromal MMP-14 expression (rho = .47, p
ISSN:	1746-1596 1746-1596
DOI:	10.1186/s13000-016-0485-3