Anti-inflammatory Therapy With Simvastatin Improves Neuroinflammation and CNS Function in a Mouse Model of Metachromatic Leukodystrophy

Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by a functional deficiency of the lysosomal enzyme arylsulfatase A. The prevailing late-infantile variant of MLD is characterized by widespread and progressive demyelination of the central nervous system (CNS) causing death dur...

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Veröffentlicht in:	Molecular therapy 2015-07, Vol.23 (7), p.1160-1168
Hauptverfasser:	Stein, Axel, Stroobants, Stijn, Gieselmann, Volkmar, D'Hooge, Rudi, Matzner, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - administration & dosage Brain Central Nervous System - drug effects Central Nervous System - physiopathology Chemokine CCL2 - biosynthesis Chemokine CCL4 - biosynthesis Chemokines Cytokines Demyelinating Diseases - drug therapy Demyelinating Diseases - pathology Disease Disease Models, Animal Enzymes Humans Inflammation - drug therapy Inflammation - physiopathology Leukodystrophy, Metachromatic - drug therapy Leukodystrophy, Metachromatic - immunology Life expectancy LSD Lysergic acid diethylamide Mice Morphology Nervous system Original Proteins Simvastatin - administration & dosage Spinal cord Spinal Cord - drug effects Spinal Cord - pathology Tumor Necrosis Factor-alpha - biosynthesis Tumor necrosis factor-TNF
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