The use of recombinant morphogenic protein-2(rhBMP-2) in children undergoing revision surgery for persistent non-union

The purpose of the study was to evaluate the safety and efficacy with the use of BMP-2 for treating persistent non-unions in children with underlying complex conditions. Between October 2006 and November 2010 in our unit, 15 patients were treated with rhBMP-2 to enhance bone union. There were nine f...

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Veröffentlicht in:Strategies in trauma and limb reconstruction 2016-04, Vol.11 (1), p.53-58
Hauptverfasser: Papanna, Madhavan C., Saldanha, K. A., Kurian, Binu, Fernandes, James A., Jones, Stan
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Sprache:eng
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Zusammenfassung:The purpose of the study was to evaluate the safety and efficacy with the use of BMP-2 for treating persistent non-unions in children with underlying complex conditions. Between October 2006 and November 2010 in our unit, 15 patients were treated with rhBMP-2 to enhance bone union. There were nine females and six males with a mean age of 9.5 years (range 4–15) at time of surgery. Seventy-five per cent of the patients required revision of internal fixation with insertion of rhBMP-2 to the non-union site, and the reminder had freshening of the non-union site with rhBMP-2 application. Patients had undergone a mean of 2 (1–5) operations prior to implantation of rhBMP-2. All the patients in the study group were available for review with mean follow-up of 44 months (range 21–70). The mean time to union was 16 weeks (range 10–28 weeks). No adverse events related to BMP-2 application were noted in our study group. Healing occurred clinically and radiographically in 16 of the 17 sites. Our study demonstrates that BMP-2 enhances healing of the persistent non-unions without any adverse events
ISSN:1828-8936
1828-8928
1828-8928
DOI:10.1007/s11751-016-0251-9