Myxoma Virus Induces Ligand Independent Extrinsic Apoptosis in Human Myeloma Cells

Myxoma Virus Induces Ligand Independent Extrinsic Apoptosis in Human Myeloma Cells

Micro-Abstract We have previously shown that the myxoma virus kills human myeloma cells. Here we show that this killing occurs because of the ligand-independent activation of caspase-8. We hypothesize that this activation is the result of viral host protein shutoff depleting a variety of cellular in...

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Veröffentlicht in:Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2016-04, Vol.16 (4), p.203-212
Hauptverfasser: Bartee, Mee Y, Dunlap, Katherine M, Bartee, Eric
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Caspase-8
Cell Death
cIAPs
Hematology, Oncology and Palliative Medicine
Host protein shutoff
Humans
Multiple Myeloma - genetics
Multiple Myeloma - pathology
Myxoma virus - genetics
Oncolytics
Resistance
Signal Transduction
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Zusammenfassung:Micro-Abstract We have previously shown that the myxoma virus kills human myeloma cells. Here we show that this killing occurs because of the ligand-independent activation of caspase-8. We hypothesize that this activation is the result of viral host protein shutoff depleting a variety of cellular inhibitors of apoptosis.
ISSN:2152-2650
2152-2669
DOI:10.1016/j.clml.2015.12.005