Determination of Sequences Required for Human Endogenous Retrovirus K Transduction and Its Recognition by Foreign Retroviral Virions

Determination of Sequences Required for Human Endogenous Retrovirus K Transduction and Its Recognition by Foreign Retroviral Virions

Sequences necessary for transduction of human endogenous retrovirus (HERV)-Kcon, a consensus of the HERV-K(HML-2) family, were analyzed and found to reside in the leader/gag region. They act in an orientation-dependent way and consist of at least two sites working together. Having defined these sequ...

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Veröffentlicht in:Journal of virology 2015-12, Vol.90 (6), p.3243-3246
Hauptverfasser: Erlwein, Otto, Sweeney, Nathan P, de Leon, Raffaele, Wills, Gillian, Robinson, Mark J, McClure, Myra O
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Sprache:eng
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Cell Line
DNA, Viral - genetics
Endogenous Retroviruses - genetics
Gene Products, gag - genetics
Genetic Therapy - methods
Genetic Vectors
HIV-1 - genetics
Humans
Leukemia Virus, Murine - genetics
Transduction, Genetic
Virus-Cell Interactions
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container_end_page 3246
container_issue 6
container_start_page 3243
container_title Journal of virology
container_volume 90
creator Erlwein, Otto
Sweeney, Nathan P
de Leon, Raffaele
Wills, Gillian
Robinson, Mark J
McClure, Myra O
description Sequences necessary for transduction of human endogenous retrovirus (HERV)-Kcon, a consensus of the HERV-K(HML-2) family, were analyzed and found to reside in the leader/gag region. They act in an orientation-dependent way and consist of at least two sites working together. Having defined these sequences, we exploited this information to produce a simple system to investigate to what extent virions of HERV-Kcon, murine leukemia virus, and HIV-1 have the ability to transduce each other's genomes, leading to potential contamination of gene therapy vectors.
doi_str_mv 10.1128/JVI.02731-15
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subjects Cell Line
DNA, Viral - genetics
Endogenous Retroviruses - genetics
Gene Products, gag - genetics
Genetic Therapy - methods
Genetic Vectors
HIV-1 - genetics
Humans
Leukemia Virus, Murine - genetics
Transduction, Genetic
Virus-Cell Interactions
title Determination of Sequences Required for Human Endogenous Retrovirus K Transduction and Its Recognition by Foreign Retroviral Virions
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