Adaptation of the inflammatory immune response across pregnancy and postpartum in Black and White women

Highlights • We examined LPS-stimulated cytokine responses across pregnancy and postpartum. • IL-6, TNF-α, and IL-1β production increased from early to late pregnancy. • Subsequent declines approaching early pregnancy values were seen at postpartum. • Minimal differences were observed among Black ve...

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Veröffentlicht in:	Journal of reproductive immunology 2016-04, Vol.114, p.27-31
Hauptverfasser:	Gillespie, Shannon L, Porter, Kyle, Christian, Lisa M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult African Americans Cytokines Cytokines - blood Cytokines - immunology European Continental Ancestry Group Female Humans Immunology Inflammation Inflammation Mediators - blood Inflammation Mediators - immunology Lipopolysaccharide Obstetrics and Gynecology Postpartum Postpartum Period - blood Postpartum Period - immunology Pregnancy Pregnancy - blood Pregnancy - immunology Race Racial disparities Stimulated cytokine production
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Beschreibung
Zusammenfassung:	Highlights • We examined LPS-stimulated cytokine responses across pregnancy and postpartum. • IL-6, TNF-α, and IL-1β production increased from early to late pregnancy. • Subsequent declines approaching early pregnancy values were seen at postpartum. • Minimal differences were observed among Black versus White women. • Future data on adaptation in healthy versus disordered pregnancy would be informative.
ISSN:	0165-0378 1872-7603
DOI:	10.1016/j.jri.2016.02.001