Mitochondrial redox status as a target for cardiovascular disease

Highlights • Mitochondrial ROS and dynamics play a role in cardiovascular diseases. • Mitochondrial fusion–fission pathways regulate cardiomyocyte function. • Mitochondrial targets are useful in cardioprotection.

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Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in pharmacology 2016-04, Vol.27, p.50-55
Hauptverfasser:	Walters, James W, Amos, Deborah, Ray, Kristeena, Santanam, Nalini
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Antioxidants - therapeutic use Cardiotonic Agents - pharmacology Cardiotonic Agents - therapeutic use Cardiovascular Diseases - drug therapy Cardiovascular Diseases - metabolism Humans Internal Medicine Medical Education Mitochondria - drug effects Oxidation-Reduction - drug effects Oxidative Stress - drug effects Reactive Oxygen Species - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Mitochondrial ROS and dynamics play a role in cardiovascular diseases. • Mitochondrial fusion–fission pathways regulate cardiomyocyte function. • Mitochondrial targets are useful in cardioprotection.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2016.01.006