Developmental ethanol exposure-induced sleep fragmentation predicts adult cognitive impairment

Highlights • Developmental ethanol exposure induces slow-wave sleep fragmentation in adults. • Early ethanol-induced sleep fragmentation correlates with cognitive impairment. • Early ethanol also impairs sleep plasticity following conditioning. • Life-long sleep disruption may be a critical factor i...

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Veröffentlicht in:	Neuroscience 2016-05, Vol.322, p.18-27
Hauptverfasser:	Wilson, D.A, Masiello, K, Lewin, M.P, Hui, M, Smiley, J.F, Saito, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol-Related Disorders - physiopathology Animals Body Temperature - physiology Central Nervous System Depressants - toxicity circadian rhythm Circadian Rhythm - physiology Cognitive Dysfunction - diagnosis Cognitive Dysfunction - physiopathology Conditioning (Psychology) - physiology Disease Models, Animal Ethanol - toxicity Fear - physiology fetal alcohol disorder insomnia Memory - physiology Mice, Inbred C57BL Motor Activity - physiology Neurology Prognosis Sleep - physiology Sleep Deprivation - physiopathology sleep fragmentation slow-wave sleep
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Zusammenfassung:	Highlights • Developmental ethanol exposure induces slow-wave sleep fragmentation in adults. • Early ethanol-induced sleep fragmentation correlates with cognitive impairment. • Early ethanol also impairs sleep plasticity following conditioning. • Life-long sleep disruption may be a critical factor in cognitive disability following early ethanol.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.02.020