Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links

Highlights • Disrupted synaptic function is common across mouse models of ASDs. • The synapses affected and the magnitude and direction of effects are inconsistent. • Overlapping molecular cascades include mGluR5, BDNF/TrkB, and mTOR signaling. • The developmental origin and circuits underlying the...

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Veröffentlicht in:	Neuroscience 2016-05, Vol.321, p.3-23
Hauptverfasser:	Hulbert, S.W, Jiang, Y.-H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals autism mouse models Autism Spectrum Disorder - genetics Autism Spectrum Disorder - metabolism Autism Spectrum Disorder - psychology Brain - metabolism Disease Models, Animal Epigenesis, Genetic Fmr1 Mecp2 Mice, Mutant Strains Mutation Neurology Pten Shank3 Signal Transduction Ube3a
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Zusammenfassung:	Highlights • Disrupted synaptic function is common across mouse models of ASDs. • The synapses affected and the magnitude and direction of effects are inconsistent. • Overlapping molecular cascades include mGluR5, BDNF/TrkB, and mTOR signaling. • The developmental origin and circuits underlying the disorders remain largely unknown.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.12.040