Urinary myeloid IgA Fc alpha receptor (CD89) and transglutaminase-2 as new biomarkers for active IgA nephropathy and henoch-Schönlein purpura nephritis

Urinary myeloid IgA Fc alpha receptor (CD89) and transglutaminase-2 as new biomarkers for active IgA nephropathy and henoch-Schönlein purpura nephritis

IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis (HSPN) are glomerular diseases that share a common and central pathogenic mechanism. The formation of immune complexes containing IgA1, myeloid IgA Fc alpha receptor (FcαRI/CD89) and transglutaminase-2 (TG2) is observed in both conditions...

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Veröffentlicht in:BBA clinical 2016-06, Vol.5, p.79-84
Hauptverfasser: Moresco, Rafael N., Speeckaert, Marijn M., Zmonarski, Slawomir C., Krajewska, Magdalena, Komuda-Leszek, Ewa, Perkowska-Ptasinska, Agnieszka, Gesualdo, Loreto, Rocchetti, Maria T., Delanghe, Sigurd E., Vanholder, Raymond, Van Biesen, Wim, Delanghe, Joris R.
Format: Artikel
Sprache:eng
Schlagworte:
Henoch-Schönlein purpura nephritis
IgA nephropathy
Myeloid IgA Fc alpha receptor
Regular
Transglutaminase-2
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Zusammenfassung:IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis (HSPN) are glomerular diseases that share a common and central pathogenic mechanism. The formation of immune complexes containing IgA1, myeloid IgA Fc alpha receptor (FcαRI/CD89) and transglutaminase-2 (TG2) is observed in both conditions. Therefore, urinary CD89 and TG2 could be potential biomarkers to identify active IgAN/HSPN. In this multicenter study, 160 patients with IgAN or HSPN were enrolled. Urinary concentrations of CD89 and TG2, as well as some other biochemical parameters, were measured. Urinary CD89 and TG2 were lower in patients with active IgAN/HSPN compared to IgAN/HSPN patients in complete remission (P
ISSN:2214-6474
2214-6474
DOI:10.1016/j.bbacli.2016.02.002