Associations between nitric oxide synthase 3 gene polymorphisms and preeclampsia risk: a meta-analysis

Previous studies have examined the role of three NOS3 gene polymorphisms [G894T, T-786C and the variable number of tandem repeats 4b/a (VNTR 4b/a)] in the susceptibility to preeclampsia with inconclusive findings. We therefore conducted an updated meta-analysis by including more studies. The most ap...

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Veröffentlicht in:	Scientific reports 2016-03, Vol.6 (1), p.23407-23407, Article 23407
Hauptverfasser:	Zeng, Fangfang, Zhu, Sui, Wong, Martin Chi-Sang, Yang, Zuyao, Tang, Jinling, Li, Keshen, Su, Xuefen
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/721 692/499 Adult Case-Control Studies Female Gene polymorphism Genetic Predisposition to Disease Genotype Genotype & phenotype Humanities and Social Sciences Humans Meta-analysis multidisciplinary Nitric oxide Nitric Oxide Synthase Type III - genetics Nitric-oxide synthase NOS3 protein Polymorphism Polymorphism, Single Nucleotide Pre-eclampsia Pre-Eclampsia - genetics Preeclampsia Pregnancy Risk Factors Science Young Adult
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Zusammenfassung:	Previous studies have examined the role of three NOS3 gene polymorphisms [G894T, T-786C and the variable number of tandem repeats 4b/a (VNTR 4b/a)] in the susceptibility to preeclampsia with inconclusive findings. We therefore conducted an updated meta-analysis by including more studies. The most appropriate genetic model was chosen for each polymorphism by using a well-established method. Pooled results indicated that, compared with the GT + GG genotype, the TT genotype of G894T was associated with an increased risk of preeclampsia (odds ratio (OR) = 1.46; 95% confidence interval (CI) = 1.21–1.77, P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep23407