Acute Cryptococcal Immune Reconstitution Inflammatory Syndrome in a Patient on Natalizumab

Acute Cryptococcal Immune Reconstitution Inflammatory Syndrome in a Patient on Natalizumab

Presented is the first case of acute immune reconstitution inflammatory syndrome (IRIS)-associated cryptococcal meningoencephalitis in a patient on natalizumab for multiple sclerosis. The patient developed acute cerebral edema after initiation of amphotericin B. We propose several mechanisms that ex...

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Veröffentlicht in:Open forum infectious diseases 2016-01, Vol.3 (1), p.ofw038-ofw038
Hauptverfasser: Gundacker, Nathan D., Jordan, Stephen J., Jones, Benjamin A., Drwiega, Joseph C., Pappas, Peter G.
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Sprache:eng
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Zusammenfassung:Presented is the first case of acute immune reconstitution inflammatory syndrome (IRIS)-associated cryptococcal meningoencephalitis in a patient on natalizumab for multiple sclerosis. The patient developed acute cerebral edema after initiation of amphotericin B. We propose several mechanisms that explain the acuity of IRIS in this specific patient population and suggest possible therapies.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofw038