Potential Diagnostic and Prognostic Value of Plasma Circulating MicroRNA-182 in Human Glioma

Previous studies showed the aberrant expression of microRNA-182 (miR-182) in glioma tissue. However, the exact role of circulating miR-182 in glioma remains unclear. Here, we confirmed the expression of plasma circulating miR-182 in glioma patients, and further explored its potential diagnostic and...

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Veröffentlicht in:	Medical science monitor 2016-03, Vol.22, p.855-862
Hauptverfasser:	Xiao, Yilei, Zhang, Lina, Song, Zikun, Guo, Chuanjun, Zhu, Jianxin, Li, Zhongmin, Zhu, Shugan
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Neoplasms - blood Brain Neoplasms - diagnosis Brain Neoplasms - genetics Case-Control Studies Clinical Research Disease-Free Survival Female Gene Expression Regulation, Neoplastic Glioma - blood Glioma - diagnosis Glioma - genetics Humans Kaplan-Meier Estimate Male MicroRNAs - blood MicroRNAs - genetics Middle Aged Multivariate Analysis Prognosis ROC Curve
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Beschreibung
Zusammenfassung:	Previous studies showed the aberrant expression of microRNA-182 (miR-182) in glioma tissue. However, the exact role of circulating miR-182 in glioma remains unclear. Here, we confirmed the expression of plasma circulating miR-182 in glioma patients, and further explored its potential diagnostic and prognostic value. Real-time quantitative PCR (RT-PCR) was used to measure circulating cell-free miR-182 from 112 glioma patients and 54 healthy controls. Our findings showed that the level of circulating miR-182 in glioma patients was higher than that in healthy controls (P
ISSN:	1643-3750 1234-1010 1643-3750
DOI:	10.12659/msm.897164