During Infection, Theiler's Virions Are Cleaved by Caspases and Disassembled into Pentamers

During Infection, Theiler's Virions Are Cleaved by Caspases and Disassembled into Pentamers

Infected macrophages in spinal cords of mice persistently infected with Theiler's murine encephalomyelitis virus (TMEV) undergo apoptosis, resulting in restricted virus yields, as do infected macrophages in culture. Apoptosis of murine macrophages in culture occurs via the intrinsic pathway lat...

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Veröffentlicht in:Journal of virology 2016-04, Vol.90 (7), p.3573-3583
Hauptverfasser: Arslan, Sevim Yildiz, Son, Kyung-No, Lipton, Howard L
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Apoptosis
Caspases - metabolism
Cells, Cultured
Cellular Response to Infection
Cricetinae
Macrophages - virology
Mice
Proteolysis
Theilovirus - physiology
Viral Load
Virion - metabolism
Virus Assembly
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Zusammenfassung:Infected macrophages in spinal cords of mice persistently infected with Theiler's murine encephalomyelitis virus (TMEV) undergo apoptosis, resulting in restricted virus yields, as do infected macrophages in culture. Apoptosis of murine macrophages in culture occurs via the intrinsic pathway later in infection (>10 h postinfection [p.i.]) after maximal virus titers (150 to 200 PFU/cell) have been reached, with loss of most infectious virus (
ISSN:0022-538X
1098-5514
1098-5514
DOI:10.1128/JVI.03035-15