Hyperactivated mTOR and JAK2/STAT3 Pathways: Molecular Drivers and Potential Therapeutic Targets of Inflammatory and Invasive Ductal Breast Cancers After Neoadjuvant Chemotherapy

Micro-Abstract: Activation of the phosphatidylinositide-3-kinase/mammalian target of rapamycin and Janus kinase/signal transducer and activator of transcription pathways are described in inflammatory breast cancer (IBC) preclinical data. This retrospective analysis of IBC and invasive ductal carcino...

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Veröffentlicht in:	Clinical breast cancer 2016-04, Vol.16 (2), p.113-122.e1
Hauptverfasser:	Jhaveri, Komal, Teplinsky, Eleonora, Silvera, Deborah, Valeta-Magara, Amanda, Arju, Rezina, Giashuddin, Shah, Sarfraz, Yasmeen, Alexander, Melissa, Darvishian, Farbod, Levine, Paul H, Hashmi, Salman, Zolfaghari, Ladan, Hoffman, Heather J, Singh, Baljit, Goldberg, Judith D, Hochman, Tsivia, Formenti, Silvia, Esteva, Francisco J, Moran, Meena S, Schneider, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - pharmacology Biomarkers Biomarkers, Tumor - metabolism Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal, Breast - drug therapy Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Female Follow-Up Studies Hematology, Oncology and Palliative Medicine Humans Immunoenzyme Techniques Inflammatory breast cancer Inflammatory Breast Neoplasms - drug therapy Inflammatory Breast Neoplasms - metabolism Inflammatory Breast Neoplasms - pathology Janus Kinase 2 - metabolism Middle Aged Neoadjuvant Therapy Neoplasm Invasiveness Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Neoplasm Staging Obstetrics and Gynecology Prognosis Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Resistance to chemotherapy Signal Transduction - drug effects Signaling pathways STAT3 Transcription Factor - metabolism Survival Rate Targeted therapies TOR Serine-Threonine Kinases - metabolism
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Zusammenfassung:	Micro-Abstract: Activation of the phosphatidylinositide-3-kinase/mammalian target of rapamycin and Janus kinase/signal transducer and activator of transcription pathways are described in inflammatory breast cancer (IBC) preclinical data. This retrospective analysis of IBC and invasive ductal carcinoma tumor tissues treated with neoadjuvant chemotherapy showed pathway activity compared with untreated invasive ductal carcinoma, which suggests a potential mechanism of resistance and supports a potential role for targeting these pathways in prospective studies.
ISSN:	1526-8209 1938-0666
DOI:	10.1016/j.clbc.2015.11.006