Blocking Cancer Growth with Less POMP or Proteasomes

Although proteasomes are critical in cell regulation and cancer therapy, little is known about the factors regulating proteasome content or activity. In this issue, Zhang et al. (2015) report that miR-101 suppresses the expression of chaperone POMP and 20S assembly, and certain cancers raise proteas...

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Veröffentlicht in:Molecular cell 2015-07, Vol.59 (2), p.143-145
Hauptverfasser: Goldberg, Alfred L., Zhao, Jinghui, Collins, Galen A.
Format: Artikel
Sprache:eng
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Zusammenfassung:Although proteasomes are critical in cell regulation and cancer therapy, little is known about the factors regulating proteasome content or activity. In this issue, Zhang et al. (2015) report that miR-101 suppresses the expression of chaperone POMP and 20S assembly, and certain cancers raise proteasome content by losing miR-101. Although proteasomes are critical in cell regulation and cancer therapy, little is known about the factors regulating proteasome content or activity. In this issue, Zhang et al. (2015) report that miR-101 suppresses the expression of chaperone POMP and 20S assembly, and certain cancers raise proteasome content by losing miR-101.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2015.07.005