Pin1-mediated Modification Prolongs the Nuclear Retention of β-Catenin in Wnt3a-induced Osteoblast Differentiation

The canonical Wnt signaling pathway, in which β-catenin nuclear localization is a crucial step, plays an important role in osteoblast differentiation. Pin1, a prolyl isomerase, is also known as a key enzyme in osteogenesis. However, the role of Pin1 in canonical Wnt signal-induced osteoblast differe...

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Veröffentlicht in:	The Journal of biological chemistry 2016-03, Vol.291 (11), p.5555-5565
Hauptverfasser:	Shin, Hye-Rim, Islam, Rabia, Yoon, Won-Joon, Lee, Taegyung, Cho, Young-Dan, Bae, Han-sol, Kim, Bong-Su, Woo, Kyung-Mi, Baek, Jeong-Hwa, Ryoo, Hyun-Mo
Format:	Artikel
Sprache:	eng
Schlagworte:	adenomatous polyposis coli (APC) Animals beta Catenin - metabolism Cell Differentiation Cell Line Cell Nucleus - genetics Cell Nucleus - metabolism HEK293 Cells Humans Mice Mice, Knockout NIMA-Interacting Peptidylprolyl Isomerase nuclear translocation osteoblast Osteoblasts - cytology Osteoblasts - metabolism Osteogenesis peptidyl prolyl cis-trans isomerization peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) Peptidylprolyl Isomerase - genetics Peptidylprolyl Isomerase - metabolism Proteolysis Signal Transduction Wnt signaling Wnt3A Protein - metabolism β-catenin
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