BRAFV600E induces ABCB1 /P-glycoprotein expression and drug resistance in B-cells via AP-1 activation

BRAFV600E induces ABCB1 /P-glycoprotein expression and drug resistance in B-cells via AP-1 activation

Highlights • A new inducible cell line system was used to determine targets of mutant BRAF in B-cells. • One such target is ABCB1 /P-gp, suggesting the use of BRAF pathway inhibitors with therapies that include P-gp substrates.

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Veröffentlicht in:Leukemia research 2015-11, Vol.39 (11), p.1270-1277
Hauptverfasser: Tsai, Yo-Ting, Lozanski, Gerard, Lehman, Amy, Sass, Ellen J, Hertlein, Erin, Salunke, Santosh B, Chen, Ching-Shih, Grever, Michael R, Byrd, John C, Lucas, David M
Format: Artikel
Sprache:eng
Schlagworte:
ABCB1
B-cell
BRAF
Hematology, Oncology and Palliative Medicine
Leukemia
Lymphoma
P-glycoprotein
Vemurafenib
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Zusammenfassung:Highlights • A new inducible cell line system was used to determine targets of mutant BRAF in B-cells. • One such target is ABCB1 /P-gp, suggesting the use of BRAF pathway inhibitors with therapies that include P-gp substrates.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2015.08.017