Fat Matters: Understanding the Role of Adipose Tissue in Health in HIV Infection

More than one-third of adults in the USA are obese and obesity-related disease accounts for some of the leading causes of preventable death. Mid-life obesity may be a strong predictor of physical function impairment later in life regardless of body mass index (BMI) in older age, highlighting the ben...

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Veröffentlicht in:	Current HIV/AIDS reports 2016-02, Vol.13 (1), p.20-30
Hauptverfasser:	Erlandson, Kristine M., Lake, Jordan E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - pathology Adipose Tissue - cytology Adipose Tissue - physiopathology Anti-HIV Agents - therapeutic use Antiretroviral Therapy, Highly Active Body Fat Distribution HIV Infections - drug therapy HIV Infections - pathology HIV Infections - virology HIV Pathogenesis and Treatment (AL Landay Humans Lipodystrophy - complications Lipodystrophy - epidemiology Lipodystrophy - therapy Medicine Medicine & Public Health Obesity - complications Obesity - epidemiology Obesity - therapy Section Editor Topical Collection on HIV Pathogenesis and Treatment United States - epidemiology
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Beschreibung
Zusammenfassung:	More than one-third of adults in the USA are obese and obesity-related disease accounts for some of the leading causes of preventable death. Mid-life obesity may be a strong predictor of physical function impairment later in life regardless of body mass index (BMI) in older age, highlighting the benefits of obesity prevention on health throughout the lifespan. Adipose tissue disturbances including lipodystrophy and obesity are prevalent in the setting of treated and untreated HIV infection. This article will review current knowledge on fat disturbances in HIV-infected persons, including therapeutic options and future directions.
ISSN:	1548-3568 1548-3576
DOI:	10.1007/s11904-016-0298-8