Suppression of the invasive potential of Glioblastoma cells by mTOR inhibitors involves modulation of NFκB and PKC-α signaling

Glioblastoma (GBM) is the most aggressive type of brain tumors in adults with survival period

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Veröffentlicht in:	Scientific reports 2016-03, Vol.6 (1), p.22455-22455, Article 22455
Hauptverfasser:	Chandrika, Goparaju, Natesh, Kumar, Ranade, Deepak, Chugh, Ashish, Shastry, Padma
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/95 14 38 38/90 631/67 692/4028/67/1922 82 96 Antineoplastic Agents - pharmacology Brain Neoplasms - drug therapy Brain Neoplasms - pathology Cell Line, Tumor Cell Movement - drug effects Glioblastoma - drug therapy Glioblastoma - pathology Humanities and Social Sciences Humans Indoles - pharmacology Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism multidisciplinary Naphthyridines - pharmacology Neoplasm Invasiveness - prevention & control NF-kappa B - metabolism Phenylacetates - pharmacology Protein Kinase C-alpha - metabolism Purines - pharmacology Science Signal Transduction - drug effects Sirolimus - pharmacology TOR Serine-Threonine Kinases - antagonists & inhibitors Tumor Microenvironment - drug effects Tumor Necrosis Factor-alpha - metabolism Vascular Endothelial Growth Factor A - metabolism
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Zusammenfassung:	Glioblastoma (GBM) is the most aggressive type of brain tumors in adults with survival period
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep22455