Reciprocal Changes of Circulating Long Non-Coding RNAs ZFAS1 and CDR1AS Predict Acute Myocardial Infarction

This study sought to evaluate the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers for acute myocardial infarction (AMI). We measured the circulating levels of 15 individual lncRNAs, known to be relevant to cardiovascular disease, using the whole blood samples collected from 103...

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Veröffentlicht in:	Scientific reports 2016-03, Vol.6 (1), p.22384-22384, Article 22384
Hauptverfasser:	Zhang, Ying, Sun, Lihua, Xuan, Lina, Pan, Zhenwei, Li, Kang, Liu, Shuangshuang, Huang, Yuechao, Zhao, Xuyun, Huang, Lihua, Wang, Zhiguo, Hou, Yan, Li, Junnan, Tian, Ye, Yu, Jiahui, Han, Hui, Liu, Yanhong, Gao, Fei, Zhang, Yong, Wang, Shu, Du, Zhimin, Lu, Yanjie, Yang, Baofeng
Format:	Artikel
Sprache:	eng
Schlagworte:	38/90 692/4019/592/75/2/1674 692/53/2421 Animals Antisense RNA Biomarkers Biomarkers - blood Blood Cardiac arrhythmia Cardiovascular diseases Complementarity-determining region 1 Disease Models, Animal Heart attacks Humanities and Social Sciences Humans Mice Mice, Inbred C57BL Middle Aged multidisciplinary Myocardial infarction Myocardial Infarction - blood Myocardial Infarction - diagnosis Prognosis RNA, Long Noncoding - blood Rodents Science Zinc finger proteins
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Zusammenfassung:	This study sought to evaluate the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers for acute myocardial infarction (AMI). We measured the circulating levels of 15 individual lncRNAs, known to be relevant to cardiovascular disease, using the whole blood samples collected from 103 AMI patients, 149 non-AMI subjects and 95 healthy volunteers. We found that only two of them, Zinc finger antisense 1 ( ZFAS1 ) and Cdr1 antisense ( CDR1AS ), showed significant differential expression between AMI patients and control subjects. Circulating level of ZFAS1 was significantly lower in AMI (0.74 ± 0.07) than in non-AMI subjects (1.0 ± 0.05, P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep22384