Prenatal toluene exposure impairs performance in the Morris Water Maze in adolescent rats

Highlights • Prenatal toluene exposure impairs longer term reversal learning in rats in the Morris Water Maze. • Prenatal toluene exposure impairs long-term, but not immediate, water maze probe trial performance. • Solvent abuse during pregnancy potentially has life-long implication for behavior and...

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Veröffentlicht in:	Neuroscience 2017-02, Vol.342, p.180-187
Hauptverfasser:	Callan, S.P, Hannigan, J.H, Bowen, S.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Female Male Maze Learning - drug effects Maze Learning - physiology Neurology organic solvents (toluene) Pregnancy Prenatal Exposure Delayed Effects - psychology prenatal exposures Psychological Tests rats Rats, Sprague-Dawley Reversal Learning - drug effects Reversal Learning - physiology Sexual Maturation Solvents - toxicity spatial learning and memory Spatial Memory - drug effects Spatial Memory - physiology Substance-Related Disorders - complications Substance-Related Disorders - physiopathology Toluene - toxicity
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Zusammenfassung:	Highlights • Prenatal toluene exposure impairs longer term reversal learning in rats in the Morris Water Maze. • Prenatal toluene exposure impairs long-term, but not immediate, water maze probe trial performance. • Solvent abuse during pregnancy potentially has life-long implication for behavior and cognitive functioning in offspring.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.08.050