Autism and Cancer Share Risk Genes, Pathways, and Drug Targets

Autism and Cancer Share Risk Genes, Pathways, and Drug Targets

Autism is a neurodevelopmental disorder, diagnosed behaviorally by social and communication deficits, repetitive behaviors, and restricted interests. Recent genome-wide exome sequencing has revealed extensive overlap in risk genes for autism and for cancer. Understanding the genetic commonalities of...

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Veröffentlicht in:Trends in genetics 2016-03, Vol.32 (3), p.139-146
Hauptverfasser: Crawley, Jacqueline N, Heyer, Wolf-Dietrich, LaSalle, Janine M
Format: Artikel
Sprache:eng
Schlagworte:
autism
Autistic Disorder - genetics
cancer
chromatin remodeling
DNA repair
gene
Genetic Predisposition to Disease
Humans
Medical Education
Neoplasms - genetics
signaling pathway
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Zusammenfassung:Autism is a neurodevelopmental disorder, diagnosed behaviorally by social and communication deficits, repetitive behaviors, and restricted interests. Recent genome-wide exome sequencing has revealed extensive overlap in risk genes for autism and for cancer. Understanding the genetic commonalities of autism(s) and cancer(s), with a focus on mechanistic pathways, could lead to repurposed therapeutics.
ISSN:0168-9525
DOI:10.1016/j.tig.2016.01.001