Development of an Ointment Formulation Using Hot-Melt Extrusion Technology

Ointments are generally prepared either by fusion or by levigation methods. The current study proposes the use of hot-melt extrusion (HME) processing for the preparation of a polyethylene glycol base ointment. Lidocaine was used as a model drug. A modified screw design was used in this process, and...

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Veröffentlicht in:AAPS PharmSciTech 2016-02, Vol.17 (1), p.158-166
Hauptverfasser: Bhagurkar, Ajinkya M., Angamuthu, Muralikrishnan, Patil, Hemlata, Tiwari, Roshan V., Maurya, Abhijeet, Hashemnejad, Seyed Meysam, Kundu, Santanu, Murthy, S. Narasimha, Repka, Michael A.
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container_title AAPS PharmSciTech
container_volume 17
creator Bhagurkar, Ajinkya M.
Angamuthu, Muralikrishnan
Patil, Hemlata
Tiwari, Roshan V.
Maurya, Abhijeet
Hashemnejad, Seyed Meysam
Kundu, Santanu
Murthy, S. Narasimha
Repka, Michael A.
description Ointments are generally prepared either by fusion or by levigation methods. The current study proposes the use of hot-melt extrusion (HME) processing for the preparation of a polyethylene glycol base ointment. Lidocaine was used as a model drug. A modified screw design was used in this process, and parameters such as feeding rate, barrel temperature, and screw speed were optimized to obtain a uniform product. The product characteristics were compared with an ointment of similar composition prepared by conventional fusion method. The rheological properties, drug release profile, and texture characteristics of the hot-melt extruded product were similar to the conventionally prepared product. This study demonstrates a novel application of the hot-melt extrusion process in the manufacturing of topical semi-solids.
doi_str_mv 10.1208/s12249-015-0453-3
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source MEDLINE; SpringerNature Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry
subjects Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Chemistry, Pharmaceutical - methods
Drug Carriers - chemistry
Drug Compounding - methods
Drug Liberation
Hot Temperature
Ointments - chemistry
Pharmacology/Toxicology
Pharmacy
Research Article
Rheology
Theme: Pharmaceutical Thermal Processing
title Development of an Ointment Formulation Using Hot-Melt Extrusion Technology
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