Development of an Ointment Formulation Using Hot-Melt Extrusion Technology
Ointments are generally prepared either by fusion or by levigation methods. The current study proposes the use of hot-melt extrusion (HME) processing for the preparation of a polyethylene glycol base ointment. Lidocaine was used as a model drug. A modified screw design was used in this process, and...
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creator | Bhagurkar, Ajinkya M. Angamuthu, Muralikrishnan Patil, Hemlata Tiwari, Roshan V. Maurya, Abhijeet Hashemnejad, Seyed Meysam Kundu, Santanu Murthy, S. Narasimha Repka, Michael A. |
description | Ointments are generally prepared either by fusion or by levigation methods. The current study proposes the use of hot-melt extrusion (HME) processing for the preparation of a polyethylene glycol base ointment. Lidocaine was used as a model drug. A modified screw design was used in this process, and parameters such as feeding rate, barrel temperature, and screw speed were optimized to obtain a uniform product. The product characteristics were compared with an ointment of similar composition prepared by conventional fusion method. The rheological properties, drug release profile, and texture characteristics of the hot-melt extruded product were similar to the conventionally prepared product. This study demonstrates a novel application of the hot-melt extrusion process in the manufacturing of topical semi-solids. |
doi_str_mv | 10.1208/s12249-015-0453-3 |
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This study demonstrates a novel application of the hot-melt extrusion process in the manufacturing of topical semi-solids.</description><identifier>ISSN: 1530-9932</identifier><identifier>EISSN: 1530-9932</identifier><identifier>DOI: 10.1208/s12249-015-0453-3</identifier><identifier>PMID: 26628438</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Chemistry, Pharmaceutical - methods ; Drug Carriers - chemistry ; Drug Compounding - methods ; Drug Liberation ; Hot Temperature ; Ointments - chemistry ; Pharmacology/Toxicology ; Pharmacy ; Research Article ; Rheology ; Theme: Pharmaceutical Thermal Processing</subject><ispartof>AAPS PharmSciTech, 2016-02, Vol.17 (1), p.158-166</ispartof><rights>American Association of Pharmaceutical Scientists 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-4a5d734c02ee15816cda5ef5ee7adaceb9e30af2cb44bf31c0c02f07d35cb4b73</citedby><cites>FETCH-LOGICAL-c442t-4a5d734c02ee15816cda5ef5ee7adaceb9e30af2cb44bf31c0c02f07d35cb4b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766123/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766123/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26628438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhagurkar, Ajinkya M.</creatorcontrib><creatorcontrib>Angamuthu, Muralikrishnan</creatorcontrib><creatorcontrib>Patil, Hemlata</creatorcontrib><creatorcontrib>Tiwari, Roshan V.</creatorcontrib><creatorcontrib>Maurya, Abhijeet</creatorcontrib><creatorcontrib>Hashemnejad, Seyed Meysam</creatorcontrib><creatorcontrib>Kundu, Santanu</creatorcontrib><creatorcontrib>Murthy, S. Narasimha</creatorcontrib><creatorcontrib>Repka, Michael A.</creatorcontrib><title>Development of an Ointment Formulation Using Hot-Melt Extrusion Technology</title><title>AAPS PharmSciTech</title><addtitle>AAPS PharmSciTech</addtitle><addtitle>AAPS PharmSciTech</addtitle><description>Ointments are generally prepared either by fusion or by levigation methods. The current study proposes the use of hot-melt extrusion (HME) processing for the preparation of a polyethylene glycol base ointment. Lidocaine was used as a model drug. A modified screw design was used in this process, and parameters such as feeding rate, barrel temperature, and screw speed were optimized to obtain a uniform product. The product characteristics were compared with an ointment of similar composition prepared by conventional fusion method. The rheological properties, drug release profile, and texture characteristics of the hot-melt extruded product were similar to the conventionally prepared product. This study demonstrates a novel application of the hot-melt extrusion process in the manufacturing of topical semi-solids.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Compounding - methods</subject><subject>Drug Liberation</subject><subject>Hot Temperature</subject><subject>Ointments - chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Research Article</subject><subject>Rheology</subject><subject>Theme: Pharmaceutical Thermal Processing</subject><issn>1530-9932</issn><issn>1530-9932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctOwzAQRS0EglL4ADYoSzYBP_PYIKHS8hCIDV1bjjNpgxK72ElF_x6XlqpsWHnse-d4NBehC4KvCcXZjSeU8jzGRMSYCxazAzQgguE4zxk93KtP0Kn3HxhTRnJ2jE5oktCMs2yAnu9hCY1dtGC6yFaRMtFbbbqf68S6tm9UV1sTTX1tZtGj7eJXaLpo_NW53q-Fd9BzYxs7W52ho0o1Hs635xBNJ-P30WP88vbwNLp7iTXntIu5EmXKuMYUgIiMJLpUAioBkKpSaShyYFhVVBecFxUjGgdrhdOSifBUpGyIbjfcRV-0UOowqlONXLi6VW4lrarlX8XUczmzS8nTJCGUBcDVFuDsZw--k23tNTSNMmB7L0maZEJkOCXBSjZW7az3DqrdNwTLdQZyk4EMGch1BnKNv9yfb9fxu_RgoBuDD5KZgZMftncm7Owf6jfzP5R5</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Bhagurkar, Ajinkya M.</creator><creator>Angamuthu, Muralikrishnan</creator><creator>Patil, Hemlata</creator><creator>Tiwari, Roshan V.</creator><creator>Maurya, Abhijeet</creator><creator>Hashemnejad, Seyed Meysam</creator><creator>Kundu, Santanu</creator><creator>Murthy, S. 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source | MEDLINE; SpringerNature Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
subjects | Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Chemistry, Pharmaceutical - methods Drug Carriers - chemistry Drug Compounding - methods Drug Liberation Hot Temperature Ointments - chemistry Pharmacology/Toxicology Pharmacy Research Article Rheology Theme: Pharmaceutical Thermal Processing |
title | Development of an Ointment Formulation Using Hot-Melt Extrusion Technology |
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