Development of an Ointment Formulation Using Hot-Melt Extrusion Technology

Ointments are generally prepared either by fusion or by levigation methods. The current study proposes the use of hot-melt extrusion (HME) processing for the preparation of a polyethylene glycol base ointment. Lidocaine was used as a model drug. A modified screw design was used in this process, and...

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Veröffentlicht in:AAPS PharmSciTech 2016-02, Vol.17 (1), p.158-166
Hauptverfasser: Bhagurkar, Ajinkya M., Angamuthu, Muralikrishnan, Patil, Hemlata, Tiwari, Roshan V., Maurya, Abhijeet, Hashemnejad, Seyed Meysam, Kundu, Santanu, Murthy, S. Narasimha, Repka, Michael A.
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Sprache:eng
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Zusammenfassung:Ointments are generally prepared either by fusion or by levigation methods. The current study proposes the use of hot-melt extrusion (HME) processing for the preparation of a polyethylene glycol base ointment. Lidocaine was used as a model drug. A modified screw design was used in this process, and parameters such as feeding rate, barrel temperature, and screw speed were optimized to obtain a uniform product. The product characteristics were compared with an ointment of similar composition prepared by conventional fusion method. The rheological properties, drug release profile, and texture characteristics of the hot-melt extruded product were similar to the conventionally prepared product. This study demonstrates a novel application of the hot-melt extrusion process in the manufacturing of topical semi-solids.
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-015-0453-3