Effect of proteoglycans at interfaces as related to location, architecture, and mechanical cues

Highlights • Hygroscopic fibrils of entheses and interfaces also contain intrafibrillar mineral. • GAGs provide strain-adaptive features to load-bearing entheses and interfaces. • GAGs maintain biophysical cues and their absence can simulate conditions related to periodontal disease.

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Bibliographische Detailangaben
Veröffentlicht in:	Archives of oral biology 2016-03, Vol.63 (C), p.82-92
Hauptverfasser:	Kurylo, Michael P, Grandfield, Kathryn, Marshall, Grayson W, Altoe, Virginia, Aloni, Shaul, Ho, Sunita P
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adolescent Adult Advanced Basic Science BASIC BIOLOGICAL SCIENCES Dental Cementum - physiology Dentin - physiology Dentistry Glycosaminoglycans Glycosaminoglycans - physiology Humans Immunohistochemistry In Vitro Techniques Indentation Interfaces Microscopy, Atomic Force Microscopy, Electron, Scanning Molar Periodontal Ligament - physiology Proteoglycans - physiology Tissue mechanics Tissue recovery Tooth Demineralization Tooth Root - ultrastructure
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Beschreibung
Zusammenfassung:	Highlights • Hygroscopic fibrils of entheses and interfaces also contain intrafibrillar mineral. • GAGs provide strain-adaptive features to load-bearing entheses and interfaces. • GAGs maintain biophysical cues and their absence can simulate conditions related to periodontal disease.
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2015.11.021