Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles

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Veröffentlicht in:	Journal of hepatology 2016-03, Vol.64 (3), p.651-660
Hauptverfasser:	Verma, Vikas K, Li, Haiyang, Wang, Ruisi, Hirsova, Petra, Mushref, Malek, Liu, Yaming, Cao, Sheng, Contreras, Patricia C, Malhi, Harmeet, Kamath, Patrick S, Gores, Gregory J, Shah, Vijay H
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcoholic hepatitis Animals Apoptosis Caspase inhibitor Caspases - physiology CD40 Ligand - physiology CD40L Cyp2E1 Cytochrome P-450 CYP2E1 - physiology Ethanol - metabolism Ethanol - toxicity Exosomes Extracellular Vesicles - physiology Female Gastroenterology and Hepatology Hep G2 Cells Hepatocyte Hepatocytes - metabolism Humans Inflammation Liver Liver Diseases, Alcoholic - etiology Macrophage Macrophage Activation - drug effects Mice Mice, Inbred C57BL TNF-α
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