Time-dependent risk factors associated with the decline of estimated GFR in CKD patients

Background Targeting the modifiable risk factors may help halt the progression of CKD, thus risk factor analysis is better performed using the parameters in the follow-up. This study aimed to examine the time-dependent risk factors for CKD progression using time-averaged values and to investigate th...

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Veröffentlicht in:	Clinical and experimental nephrology 2016-02, Vol.20 (1), p.58-70
Hauptverfasser:	Chang, Wen-xiu, Arai, Shigeyuki, Tamura, Yoshifuru, Kumagai, Takanori, Ota, Tatsuru, Shibata, Shigeru, Fujigaki, Yoshihide, Shen, Zhong-yang, Uchida, Shunya
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anemia - epidemiology Chi-Square Distribution Comorbidity Disease Progression Female Glomerular Filtration Rate Humans Hyperphosphatemia - epidemiology Japan - epidemiology Kidney - physiopathology Linear Models Logistic Models Male Medicine Medicine & Public Health Middle Aged Multivariate Analysis Nephrology Original Original Article Prevalence Proteinuria - epidemiology Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - physiopathology Renal Insufficiency, Chronic - therapy Retrospective Studies Risk Factors Sex Factors Time Factors Urology Young Adult
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Zusammenfassung:	Background Targeting the modifiable risk factors may help halt the progression of CKD, thus risk factor analysis is better performed using the parameters in the follow-up. This study aimed to examine the time-dependent risk factors for CKD progression using time-averaged values and to investigate the characteristics of rapid progression group. Methods This is a retrospective cohort study enrolling 770 patients of CKD stage 3–4. Time-dependent parameters were calculated as time-averaged values by a trapezoidal rule. % decline of estimated GFR (eGFR) per year from entry was divided to three groups:
ISSN:	1342-1751 1437-7799
DOI:	10.1007/s10157-015-1132-0