Dual role of arginine metabolism in establishing pathogenesis

Highlights • Arginine as an energy source in the host and pathogen. • Arginine-dependent NO production. • Modulation of arginine metabolism — strategy for immune evasion by pathogens. • Bioengineered arginine tagged particles — next generation antimicrobial therapy.

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Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in microbiology 2016-02, Vol.29, p.43-48
Hauptverfasser:	Gogoi, Mayuri, Datey, Akshay, Wilson, Keith T, Chakravortty, Dipshikha
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginase - metabolism Arginine - genetics Arginine - immunology Arginine - metabolism Arginine - therapeutic use Bacteria - metabolism Bacteria - pathogenicity Bacterial Infections - immunology Bacterial Infections - microbiology Bacterial Infections - therapy Energy Metabolism Host-Pathogen Interactions Humans Immune Evasion Mice Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Pathology
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Beschreibung
Zusammenfassung:	Highlights • Arginine as an energy source in the host and pathogen. • Arginine-dependent NO production. • Modulation of arginine metabolism — strategy for immune evasion by pathogens. • Bioengineered arginine tagged particles — next generation antimicrobial therapy.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2015.10.005