Inflammation and activity augment brain-derived neurotrophic factor peripheral release

Highlights • Depolarization evoked BDNF release to nerve terminals. • BDNF released to the visceral organ in vivo. • Both BDNF and pro-BDNF content were increased in the viscera in response to inflammation. • TrkB and p75 expression/activity were increased during inflammation.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2016-03, Vol.318, p.114-121
Hauptverfasser:	Qiao, L.Y, Shen, S, Liu, M, Xia, C, Kay, J.C, Zhang, Q.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BDNF Brain-Derived Neurotrophic Factor - metabolism Ganglia, Spinal - metabolism inflammation Inflammation - metabolism Male Neurology Neurons, Afferent - metabolism periphery Protein Precursors - metabolism Rats, Sprague-Dawley receptor Receptor, trkB - metabolism release Spinal Cord - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Depolarization evoked BDNF release to nerve terminals. • BDNF released to the visceral organ in vivo. • Both BDNF and pro-BDNF content were increased in the viscera in response to inflammation. • TrkB and p75 expression/activity were increased during inflammation.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.01.018