Common mechanisms in development and disease: BMP signaling in craniofacial development
Highlights • BMP signaling is one of the key pathways regulating craniofacial development. • BMP signaling is involved in the early patterning of the head, the development of cranial neural crest cells, and facial patterning. • BMP signaling regulates development of mineralized structures, such as c...
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| Veröffentlicht in: | Cytokine & growth factor reviews 2016-02, Vol.27, p.129-139 |
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| creator | Graf, Daniel Malik, Zeba Hayano, Satoru Mishina, Yuji |
| description | Highlights • BMP signaling is one of the key pathways regulating craniofacial development. • BMP signaling is involved in the early patterning of the head, the development of cranial neural crest cells, and facial patterning. • BMP signaling regulates development of mineralized structures, such as cranial bones, maxilla, mandible, palate, and teeth. • Targeted mutations in the mouse have been instrumental to delineate the functional involvement of BMP signaling in different aspects of craniofacial development. • Gene polymorphisms and mutations in BMP pathway genes have been associated with various non-syndromic and syndromic human craniofacial malformations. • Balanced BMP signaling and its local fine-regulation is critical to organize and maintain craniofacial tissues. This has direct implications for the development of clinical applications using recombinant BMPs or BMP antagonists for tissue engineering in situ. |
| doi_str_mv | 10.1016/j.cytogfr.2015.11.004 |
| format | Article |
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This has direct implications for the development of clinical applications using recombinant BMPs or BMP antagonists for tissue engineering in situ.</description><subject>Advanced Basic Science</subject><subject>Animals</subject><subject>BMP signaling</subject><subject>Bone Morphogenetic Proteins - metabolism</subject><subject>Cleft palate</subject><subject>Congenital malformations</subject><subject>Craniofacial Abnormalities - embryology</subject><subject>Craniofacial Abnormalities - pathology</subject><subject>Craniofacial development</subject><subject>Craniofacial malformations</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Face - abnormalities</subject><subject>Face - embryology</subject><subject>Face - pathology</subject><subject>Gene targeting</subject><subject>Humans</subject><subject>Mice</subject><subject>Neural Crest - embryology</subject><subject>Neural Crest - pathology</subject><subject>Signal Transduction</subject><subject>Tooth morphogenesis</subject><issn>1359-6101</issn><issn>1879-0305</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdFuEzEQRS0Eom3gE0D7A7uM1-vdmIciiKAgFYEEiMeRY49Th107stNI-Xu8SqkKLzyNJd97R3MuYy84NBx4_2rbmOM-blxqWuCy4bwB6B6xc74cVA0C5OPyFlLVfZGfsYuct1AUQsJTdtb2QzeIgZ-zn6s4TTFUE5kbHXyecuVDZelAY9xNFPaVDrayPpPO9Lp69_lrlf0m6NGHzaw0qbii08br8aHtGXvi9Jjp-d1csB8f3n9ffayvv1x9Wr29ro2Ucl_30igrVC9aBaoHzS0Na2eUUIp0L5cgtIHB8qWDNQ3Otl0HrQPX8bXVZYgFuzzl7m7XE1lTVic94i75SacjRu3x75_gb3ATD9gNUnCQJUCeAkyKOSdy914OOJPGLd6Rxpk0co4zxwV7-XDxvesP2iJ4cxJQOf_gKWE2noIh6xOZPdro_7vi8p8EU7B7o8dfdKS8jbepFJGRY24R8Ntc99w2lwJKait-AzIWqWI</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Graf, Daniel</creator><creator>Malik, Zeba</creator><creator>Hayano, Satoru</creator><creator>Mishina, Yuji</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20160201</creationdate><title>Common mechanisms in development and disease: BMP signaling in craniofacial development</title><author>Graf, Daniel ; Malik, Zeba ; Hayano, Satoru ; Mishina, Yuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c555t-65c9d3963290960a1de7bfc9399ea65803ac07d18f0be7fd24402f0f41bda0f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Advanced Basic Science</topic><topic>Animals</topic><topic>BMP signaling</topic><topic>Bone Morphogenetic Proteins - metabolism</topic><topic>Cleft palate</topic><topic>Congenital malformations</topic><topic>Craniofacial Abnormalities - embryology</topic><topic>Craniofacial Abnormalities - pathology</topic><topic>Craniofacial development</topic><topic>Craniofacial malformations</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Face - abnormalities</topic><topic>Face - embryology</topic><topic>Face - pathology</topic><topic>Gene targeting</topic><topic>Humans</topic><topic>Mice</topic><topic>Neural Crest - embryology</topic><topic>Neural Crest - pathology</topic><topic>Signal Transduction</topic><topic>Tooth morphogenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graf, Daniel</creatorcontrib><creatorcontrib>Malik, Zeba</creatorcontrib><creatorcontrib>Hayano, Satoru</creatorcontrib><creatorcontrib>Mishina, Yuji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cytokine & growth factor reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graf, Daniel</au><au>Malik, Zeba</au><au>Hayano, Satoru</au><au>Mishina, Yuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Common mechanisms in development and disease: BMP signaling in craniofacial development</atitle><jtitle>Cytokine & growth factor reviews</jtitle><addtitle>Cytokine Growth Factor Rev</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>27</volume><spage>129</spage><epage>139</epage><pages>129-139</pages><issn>1359-6101</issn><eissn>1879-0305</eissn><abstract>Highlights • BMP signaling is one of the key pathways regulating craniofacial development. • BMP signaling is involved in the early patterning of the head, the development of cranial neural crest cells, and facial patterning. • BMP signaling regulates development of mineralized structures, such as cranial bones, maxilla, mandible, palate, and teeth. • Targeted mutations in the mouse have been instrumental to delineate the functional involvement of BMP signaling in different aspects of craniofacial development. • Gene polymorphisms and mutations in BMP pathway genes have been associated with various non-syndromic and syndromic human craniofacial malformations. • Balanced BMP signaling and its local fine-regulation is critical to organize and maintain craniofacial tissues. This has direct implications for the development of clinical applications using recombinant BMPs or BMP antagonists for tissue engineering in situ.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26747371</pmid><doi>10.1016/j.cytogfr.2015.11.004</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1359-6101 |
| ispartof | Cytokine & growth factor reviews, 2016-02, Vol.27, p.129-139 |
| issn | 1359-6101 1879-0305 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Advanced Basic Science Animals BMP signaling Bone Morphogenetic Proteins - metabolism Cleft palate Congenital malformations Craniofacial Abnormalities - embryology Craniofacial Abnormalities - pathology Craniofacial development Craniofacial malformations Epithelial-Mesenchymal Transition Face - abnormalities Face - embryology Face - pathology Gene targeting Humans Mice Neural Crest - embryology Neural Crest - pathology Signal Transduction Tooth morphogenesis |
| title | Common mechanisms in development and disease: BMP signaling in craniofacial development |
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