Common mechanisms in development and disease: BMP signaling in craniofacial development

Highlights • BMP signaling is one of the key pathways regulating craniofacial development. • BMP signaling is involved in the early patterning of the head, the development of cranial neural crest cells, and facial patterning. • BMP signaling regulates development of mineralized structures, such as c...

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Veröffentlicht in:Cytokine & growth factor reviews 2016-02, Vol.27, p.129-139
Hauptverfasser: Graf, Daniel, Malik, Zeba, Hayano, Satoru, Mishina, Yuji
Format: Artikel
Sprache:eng
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Zusammenfassung:Highlights • BMP signaling is one of the key pathways regulating craniofacial development. • BMP signaling is involved in the early patterning of the head, the development of cranial neural crest cells, and facial patterning. • BMP signaling regulates development of mineralized structures, such as cranial bones, maxilla, mandible, palate, and teeth. • Targeted mutations in the mouse have been instrumental to delineate the functional involvement of BMP signaling in different aspects of craniofacial development. • Gene polymorphisms and mutations in BMP pathway genes have been associated with various non-syndromic and syndromic human craniofacial malformations. • Balanced BMP signaling and its local fine-regulation is critical to organize and maintain craniofacial tissues. This has direct implications for the development of clinical applications using recombinant BMPs or BMP antagonists for tissue engineering in situ.
ISSN:1359-6101
1879-0305
DOI:10.1016/j.cytogfr.2015.11.004