Common mechanisms in development and disease: BMP signaling in craniofacial development
Highlights • BMP signaling is one of the key pathways regulating craniofacial development. • BMP signaling is involved in the early patterning of the head, the development of cranial neural crest cells, and facial patterning. • BMP signaling regulates development of mineralized structures, such as c...
Gespeichert in:
Veröffentlicht in: | Cytokine & growth factor reviews 2016-02, Vol.27, p.129-139 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Highlights • BMP signaling is one of the key pathways regulating craniofacial development. • BMP signaling is involved in the early patterning of the head, the development of cranial neural crest cells, and facial patterning. • BMP signaling regulates development of mineralized structures, such as cranial bones, maxilla, mandible, palate, and teeth. • Targeted mutations in the mouse have been instrumental to delineate the functional involvement of BMP signaling in different aspects of craniofacial development. • Gene polymorphisms and mutations in BMP pathway genes have been associated with various non-syndromic and syndromic human craniofacial malformations. • Balanced BMP signaling and its local fine-regulation is critical to organize and maintain craniofacial tissues. This has direct implications for the development of clinical applications using recombinant BMPs or BMP antagonists for tissue engineering in situ. |
---|---|
ISSN: | 1359-6101 1879-0305 |
DOI: | 10.1016/j.cytogfr.2015.11.004 |