David and Goliath: chemical perturbation of eukaryotes by bacteria

Environmental microbes produce biologically active small molecules that have been mined extensively as antibiotics and a smaller number of drugs that act on eukaryotic cells. It is known that there are additional bioactives to be discovered from this source. While the discovery of new antibiotics is...

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Veröffentlicht in:Journal of Industrial Microbiology & Biotechnology 2016-03, Vol.43 (2-3), p.233-248
Hauptverfasser: Ho, Louis K, Nodwell, Justin R
Format: Artikel
Sprache:eng
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Zusammenfassung:Environmental microbes produce biologically active small molecules that have been mined extensively as antibiotics and a smaller number of drugs that act on eukaryotic cells. It is known that there are additional bioactives to be discovered from this source. While the discovery of new antibiotics is challenged by the frequent discovery of known compounds, we contend that the eukaryote-active compounds may be less saturated. Indeed, despite there being far fewer eukaryotic-active natural products these molecules interact with a far richer diversity of molecular and cellular targets.
ISSN:1367-5435
1476-5535
DOI:10.1007/s10295-015-1686-6