Retrospective analysis of the influence of 25-hydroxyvitamin D on disease progression and survival in pancreatic cancer

Retrospective analysis of the influence of 25-hydroxyvitamin D on disease progression and survival in pancreatic cancer

Vitamin D deficiency is implicated in neoplastic processes in multiple organs, including the pancreas. While animal and human data have established a relationship between serum vitamin D (25(OH)D) and the development of pancreatic cancer, few studies have examined the effects of 25(OH)D on time to p...

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Veröffentlicht in:Nutrition journal 2016-02, Vol.15 (17), p.17-17, Article 17
Hauptverfasser: McGovern, Erica M, Lewis, Mark E, Niesley, Michelle L, Huynh, Nhu, Hoag, Jeffrey B
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Alfacalcidol
blood serum
Body Mass Index
Calcifediol
carcinogenesis
Care and treatment
Development and progression
disease course
Disease Progression
Female
Follow-Up Studies
Health aspects
Humans
Male
Middle Aged
Mortality
nationalities and ethnic groups
pancreas
Pancreatic cancer
pancreatic neoplasms
Pancreatic Neoplasms - blood
Pancreatic Neoplasms - drug therapy
patients
Quality of life
Retrospective Studies
Studies
Vitamin D
Vitamin D - administration & dosage
Vitamin D - analogs & derivatives
Vitamin D - blood
vitamin D deficiency
Vitamin D Deficiency - blood
Vitamin D Deficiency - drug therapy
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Zusammenfassung:Vitamin D deficiency is implicated in neoplastic processes in multiple organs, including the pancreas. While animal and human data have established a relationship between serum vitamin D (25(OH)D) and the development of pancreatic cancer, few studies have examined the effects of 25(OH)D on time to progression (TTP) and overall survival (OS) in this patient population. We hypothesize that lower baseline serum concentrations (BSC) of 25(OH)D will be associated with decreased TTP and OS. This retrospective analysis of 1222 patients with pancreatic cancer aims to identify potential relationships between 25(OH)D and both TTP and OS, while controlling for the effects of ethnicity and body mass index (BMI). Baseline 25(OH)D was divided into quartiles defined as deficient (
ISSN:1475-2891
1475-2891
DOI:10.1186/s12937-016-0135-3