Modelling the effects of cerebral microvasculature morphology on oxygen transport

Modelling the effects of cerebral microvasculature morphology on oxygen transport

Highlights • Solving for O2 transport using artificial models of the cerebral microvasculature. • O2 extraction is dependent on the transit time distribution. • Metabolic rate is dependent on the transit time distribution. • Transit time has an effect on the response of metabolic rate to step change...

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Veröffentlicht in:Medical engineering & physics 2016-01, Vol.38 (1), p.41-47
Hauptverfasser: Park, Chang Sub, Payne, Stephen J
Format: Artikel
Sprache:eng
Schlagworte:
Biological Transport
Blood flow
Brain - blood supply
Brain - metabolism
Cerebral metabolic rate
Cerebrovascular Circulation
Correlation
Extraction
Heterogeneity
Mathematical modelling
Mathematical models
Metabolism
Microcirculation
Microvessels - cytology
Microvessels - physiology
Models, Biological
Oxygen
Oxygen - metabolism
Oxygen dynamics
Oxygen extraction fraction
Radiology
Transit time
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Beschreibung
Zusammenfassung:Highlights • Solving for O2 transport using artificial models of the cerebral microvasculature. • O2 extraction is dependent on the transit time distribution. • Metabolic rate is dependent on the transit time distribution. • Transit time has an effect on the response of metabolic rate to step changes.
ISSN:1350-4533
1873-4030
DOI:10.1016/j.medengphy.2015.09.004