GATA3 haploinsufficiency does not block allergic sensitization or atopic disease

Analysis of cytokine production by CD3+CD4+CD27-CD45RO+ effector memory T cells following stimulation with phorbol 12-myristate 13-acetate (PMA)/ionomycin demonstrated a trend toward an increased frequency of IFN-Î³-producing cells and a trend toward a decreased frequency of IL-4- and IL-13-producin...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.627-629.e2
Hauptverfasser:	Lawrence, Monica G., MD, Leiding, Jennifer W., MD, Lyons, Jonathan J., MD, Hsu, Amy P., BS, Nelson, Celeste C., CRNP, Jones, Nina, RN, Fitzgerald, Alan, RN, Chien, Wade W., MD, Workman, Lisa, BA, Platts-Mills, Thomas A., MD, Brewer, Carmen, PhD, Gafni, Rachel I., MD, Stone, Kelly D., MD, PhD, Milner, Joshua D., MD, Holland, Steven M., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Allergens - immunology Allergy and Immunology Cytokines Ear diseases Food Food allergies GATA3 Transcription Factor - genetics Haploinsufficiency Hearing aids Hearing loss Humans Hypersensitivity - diagnosis Hypersensitivity - genetics Hypersensitivity - immunology Hypersensitivity, Immediate - diagnosis Hypersensitivity, Immediate - genetics Hypersensitivity, Immediate - immunology Immunoglobulin E - blood Immunoglobulin E - immunology Laboratories Lymphocytes Mutation Proteins Rodents Skin Tests Streptococcus infections T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Transcription factors
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Zusammenfassung:	Analysis of cytokine production by CD3+CD4+CD27-CD45RO+ effector memory T cells following stimulation with phorbol 12-myristate 13-acetate (PMA)/ionomycin demonstrated a trend toward an increased frequency of IFN-Î³-producing cells and a trend toward a decreased frequency of IL-4- and IL-13-producing cells in patients (GATA3+/-) compared with healthy controls (GATA3wt), although there was wide variability and this did not reach statistical significance (Fig 1). Because previous reports have suggested a TH1 bias with a concomitant impairment in TH2 cytokine production,1 we next sought to determine whether there was a defect in TH2 differentiation.
ISSN:	0091-6749 1097-6825 1097-6825
DOI:	10.1016/j.jaci.2015.06.041