Superparamagnetic Iron Oxide Nanoparticle Micelles Stabilized by Recombinant Oleosin for Targeted Magnetic Resonance Imaging

Recombinant surfactants present a new platform for stabilizing and targeting nanoparticle imaging agents. Superparamagnetic iron oxide nanoparticle‐loaded micelles for MRI contrast are stabilized by an engineered variant of the naturally occurring protein oleosin and targeted using a Her2/neu affibo...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2015-03, Vol.11 (12), p.1409-1413
Hauptverfasser:	Vargo, Kevin B., Zaki, Ajlan Al, Warden‐Rothman, Robert, Tsourkas, Andrew, Hammer, Daniel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals contrast agents Contrast Media - chemistry Dextrans - chemistry Excipients - chemistry iron oxide Iron oxides Ligands Magnetic resonance imaging Magnetic Resonance Imaging - methods Magnetite Nanoparticles - chemistry Mice Micelles MRI contrast Nanostructure oleosin Plant Proteins - chemistry Plant Proteins - genetics Platforms Receptor, ErbB-2 - genetics Receptor, ErbB-2 - pharmacokinetics Recombinant Recombinant Proteins - chemistry recombinant surfactants Surfactants targeting
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Beschreibung
Zusammenfassung:	Recombinant surfactants present a new platform for stabilizing and targeting nanoparticle imaging agents. Superparamagnetic iron oxide nanoparticle‐loaded micelles for MRI contrast are stabilized by an engineered variant of the naturally occurring protein oleosin and targeted using a Her2/neu affibody‐oleosin fusion. The recombinant oleosin platform allows simple targeting and the ability to easily swap the ligand for numerous targets.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.201402017