Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum levels of 129 metabolites as measured by the Biocrates...

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Veröffentlicht in:Nature communications 2015-06, Vol.6 (1), p.7208-7208, Article 7208
Hauptverfasser: Draisma, Harmen H. M., Pool, René, Kobl, Michael, Jansen, Rick, Petersen, Ann-Kristin, Vaarhorst, Anika A. M., Yet, Idil, Haller, Toomas, Demirkan, Ayşe, Esko, Tõnu, Zhu, Gu, Böhringer, Stefan, Beekman, Marian, van Klinken, Jan Bert, Römisch-Margl, Werner, Prehn, Cornelia, Adamski, Jerzy, de Craen, Anton J. M., van Leeuwen, Elisabeth M., Amin, Najaf, Dharuri, Harish, Westra, Harm-Jan, Franke, Lude, de Geus, Eco J. C., Hottenga, Jouke Jan, Willemsen, Gonneke, Henders, Anjali K., Montgomery, Grant W., Nyholt, Dale R., Whitfield, John B., Penninx, Brenda W., Spector, Tim D., Metspalu, Andres, Eline Slagboom, P., van Dijk, Ko Willems, ‘t Hoen, Peter A. C., Strauch, Konstantin, Martin, Nicholas G., van Ommen, Gert-Jan B., Illig, Thomas, Bell, Jordana T., Mangino, Massimo, Suhre, Karsten, McCarthy, Mark I., Gieger, Christian, Isaacs, Aaron, van Duijn, Cornelia M., Boomsma, Dorret I.
Format: Artikel
Sprache:eng
Schlagworte:
38/39
38/43
631/208/205/2138
631/208/726/649
631/443/319/320
Blood - metabolism
Genome-Wide Association Study
Humanities and Social Sciences
Humans
multidisciplinary
Polymorphism, Single Nucleotide
Science
Science (multidisciplinary)
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Zusammenfassung:Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum levels of 129 metabolites as measured by the Biocrates metabolomic platform. In a discovery sample of 7,478 individuals of European descent, we find 4,068 genome- and metabolome-wide significant ( Z -test, P
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms8208