The transfer and decay of maternal antibody against Shigella sonnei in a longitudinal cohort of Vietnamese infants

Highlights • Shigella sonnei is an emergent and highly drug resistant diarrheal pathogen. • The half-life of maternal S. sonnei IgG in infants is 43 days. • Maternal titer, antibody transfer ratio and gestational age influence birth titer. • Incidence of seroconversion in infants in southern Vietnam...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2016-02, Vol.34 (6), p.783-790
Hauptverfasser:	Thompson, Corinne N, Tu, Le Thi Phuong, Anders, Katherine L, Hieu, Nguyen Trong, Vi, Lu Lan, Chau, Nguyen Van Vinh, Duong, Vu Thuy, Chau, Nguyen Ngoc Minh, Chau, Tran Thi Hong, Tuyen, Ha Thanh, Nga, Tran Vu Thieu, Van Minh, Pham, Nhu, Tran Do Hoang, Nhi, Le Thi Quynh, Saul, Allan, Martin, Laura B, Podda, Audino, Gerke, Christiane, Thwaites, Guy, Simmons, Cameron P, Baker, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Allergy and Immunology antibodies Antibodies, Bacterial - blood Antibodies, Bacterial - chemistry Antigens Babies children confidence interval diarrhea Disease Enzyme-Linked Immunosorbent Assay Ethics Female Fetal Blood - immunology gestational age Half-Life Hospitals Humans Immune system Immunity, Maternally-Acquired immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - chemistry immunoglobulin M infancy Infant Infant, Newborn Infants Infections Longitudinal Studies Male Maternal antibody mothers Neonates O Antigens - isolation & purification pathogens placenta Placental transfer Population risk Seroconversion Shigella Shigella sonnei Umbilical cord vaccines Vietnam Vietnamese people
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Shigella sonnei is an emergent and highly drug resistant diarrheal pathogen. • The half-life of maternal S. sonnei IgG in infants is 43 days. • Maternal titer, antibody transfer ratio and gestational age influence birth titer. • Incidence of seroconversion in infants in southern Vietnam is 4/100 infant years. • Children should be vaccinated after 5 months of age if a candidate is licensed.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.12.047