Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans

Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans

BACKGROUND AND PURPOSE—The majority of genome-wide association studies (GWAS) of stroke have focused on European-ancestry populations; however, none has been conducted in African Americans, despite the disproportionately high burden of stroke in this population. The Consortium of Minority Population...

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Veröffentlicht in:Stroke (1970) 2015-08, Vol.46 (8), p.2063-2068
Hauptverfasser: Carty, Cara L, Keene, Keith L, Cheng, Yu-Ching, Meschia, James F, Chen, Wei-Min, Nalls, Mike, Bis, Joshua C, Kittner, Steven J, Rich, Stephen S, Tajuddin, Salman, Zonderman, Alan B, Evans, Michele K, Langefeld, Carl D, Gottesman, Rebecca, Mosley, Thomas H, Shahar, Eyal, Woo, Daniel, Yaffe, Kristine, Liu, Yongmei, Sale, Michèle M, Dichgans, Martin, Malik, Rainer, Longstreth, W.T, Mitchell, Braxton D, Psaty, Bruce M, Kooperberg, Charles, Reiner, Alexander, Worrall, Bradford B, Fornage, Myriam
Format: Artikel
Sprache:eng
Schlagworte:
African Americans - genetics
Case-Control Studies
Cohort Studies
Genetic Predisposition to Disease - epidemiology
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study - methods
Humans
Polymorphism, Single Nucleotide - genetics
Risk Factors
Stroke - diagnosis
Stroke - epidemiology
Stroke - genetics
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Zusammenfassung:BACKGROUND AND PURPOSE—The majority of genome-wide association studies (GWAS) of stroke have focused on European-ancestry populations; however, none has been conducted in African Americans, despite the disproportionately high burden of stroke in this population. The Consortium of Minority Population Genome-Wide Association Studies of Stroke (COMPASS) was established to identify stroke susceptibility loci in minority populations. METHODS—Using METAL, we conducted meta-analyses of GWAS in 14 746 African Americans (1365 ischemic and 1592 total stroke cases) from COMPASS, and tested genetic variants with P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.115.009044