Oct-4 is associated with gastric cancer progression and prognosis

To investigate the clinical significance of Oct-4 in the development and progression of gastric cancer. Immunohistochemistry was used to analyze Oct-4 expression in 412 gastric cancer cases. Oct-4 protein levels were upregulated in gastric cancer tissues compared with adjacent noncancerous tissues....

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Veröffentlicht in:OncoTargets and therapy 2016-01, Vol.9, p.517-522
Hauptverfasser: Jiang, Wen-Li, Zhang, Peng-Fei, Li, Guo-Feng, Dong, Jian-Hua, Wang, Xue-Song, Wang, Yuan-Yu
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Sprache:eng
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Zusammenfassung:To investigate the clinical significance of Oct-4 in the development and progression of gastric cancer. Immunohistochemistry was used to analyze Oct-4 expression in 412 gastric cancer cases. Oct-4 protein levels were upregulated in gastric cancer tissues compared with adjacent noncancerous tissues. Positive expression of Oct-4 correlated with age, depth of invasion, Lauren classification, lymph node metastasis, distant metastasis, and TNM stage. In stages I, II, and III, the 5-year survival rate of patients with high expression of Oct-4 was significantly lower than that in patients with low expression of Oct-4. In stage IV, Oct-4 expression did not correlate with the 5-year survival rate. Furthermore, multivariate analysis suggested that the depth of invasion, lymph node metastasis, distant metastasis, TNM stage, and upregulation of Oct-4 were independent prognostic factors of gastric cancer. Oct-4 protein is a useful marker in predicting tumor progression and prognosis.
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S90031