Regulation of mTORC1 by PI3K signaling

Highlights • mTORC1 activity requires the Rag and Rheb GTPases and signals from amino acids and growth factors. • Growth factor-stimulated PI3K–Akt signaling activates Rheb and mTORC1 at the lysosome. • Amino acid signaling promotes mTORC1–Rheb colocalization at the lysosome. • Akt activates Rheb by...

Ausführliche Beschreibung