Regulation of mTORC1 by PI3K signaling

Highlights • mTORC1 activity requires the Rag and Rheb GTPases and signals from amino acids and growth factors. • Growth factor-stimulated PI3K–Akt signaling activates Rheb and mTORC1 at the lysosome. • Amino acid signaling promotes mTORC1–Rheb colocalization at the lysosome. • Akt activates Rheb by...

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Veröffentlicht in:	Trends in cell biology 2015-09, Vol.25 (9), p.545-555
Hauptverfasser:	Dibble, Christian C, Cantley, Lewis C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autistic Disorder - enzymology Diabetes Mellitus - enzymology Feedback, Physiological Humans insulin Insulin - physiology Intracellular Signaling Peptides and Proteins - physiology lysosome Lysosomes - enzymology Mechanistic Target of Rapamycin Complex 1 Multiprotein Complexes - metabolism Pathology Phosphatidylinositol 3-Kinases - physiology Rag Raptor Rheb Signal Transduction TOR Serine-Threonine Kinases - metabolism TSC2
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Beschreibung
Zusammenfassung:	Highlights • mTORC1 activity requires the Rag and Rheb GTPases and signals from amino acids and growth factors. • Growth factor-stimulated PI3K–Akt signaling activates Rheb and mTORC1 at the lysosome. • Amino acid signaling promotes mTORC1–Rheb colocalization at the lysosome. • Akt activates Rheb by inducing dissociation of its GAP, the TSC complex, from the lysosome.
ISSN:	0962-8924 1879-3088
DOI:	10.1016/j.tcb.2015.06.002