Defective Angiogenesis Delays Thrombus Resolution: A Potential Pathogenetic Mechanism Underlying Chronic Thromboembolic Pulmonary Hypertension

OBJECTIVE—Restoration of patency is a natural target of vascular remodeling after venous thrombosis that involves vascular endothelial cells and smooth muscle cells, as well as leukocytes. Acute pulmonary emboli usually resolve

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Bibliographische Detailangaben
Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2014-04, Vol.34 (4), p.810-819
Hauptverfasser:	Alias, Sherin, Redwan, Bassam, Panzenböck, Adelheid, Winter, Max P, Schubert, Uwe, Voswinckel, Robert, Frey, Maria K, Jakowitsch, Johannes, Alimohammadi, Arman, Hobohm, Lukas, Mangold, Andreas, Bergmeister, Helga, Sibilia, Maria, Wagner, Erwin F, Mayer, Eckhard, Klepetko, Walter, Hölzenbein, Thomas J, Preissner, Klaus T, Lang, Irene M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angiogenic Proteins - genetics Angiogenic Proteins - metabolism Animals Cells, Cultured Chronic Disease Disease Models, Animal Endarterectomy Female Gene Expression Regulation Human Umbilical Vein Endothelial Cells - metabolism Humans Hypertension, Pulmonary - blood Hypertension, Pulmonary - etiology Hypertension, Pulmonary - genetics Hypertension, Pulmonary - surgery Macrophages - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Neovascularization, Physiologic - genetics Time Factors Vascular Endothelial Growth Factor Receptor-2 - deficiency Vascular Endothelial Growth Factor Receptor-2 - genetics Venous Thromboembolism - blood Venous Thromboembolism - complications Venous Thromboembolism - genetics Venous Thromboembolism - surgery Venous Thrombosis - blood Venous Thrombosis - complications Venous Thrombosis - genetics Venous Thrombosis - surgery
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Beschreibung
Zusammenfassung:	OBJECTIVE—Restoration of patency is a natural target of vascular remodeling after venous thrombosis that involves vascular endothelial cells and smooth muscle cells, as well as leukocytes. Acute pulmonary emboli usually resolve
ISSN:	1079-5642 1524-4636
DOI:	10.1161/ATVBAHA.113.302991