Multimodal MRI characterization of experimental subarachnoid hemorrhage

Highlights • Subarachnoid hemorrhage (SAH) results in transient vasospasm and venous abnormality. • SAH transiently reduces basal cerebral blood flow and its response to hypercapnia. • SAH causes transient diffusion change but no ischemic brain injury. • Both SAH and control rats show reduced open-f...

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Veröffentlicht in:	Neuroscience 2016-03, Vol.316, p.53-62
Hauptverfasser:	Sun, Y, Shen, Q, Watts, L.T, Muir, E.R, Huang, S, Yang, G.-Y, Suarez, J.I, Duong, T.Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - blood supply Brain - diagnostic imaging Brain - pathology Brain Mapping cerebral ischemia Disease Models, Animal Hemodynamics Image Processing, Computer-Assisted Locomotion Magnetic Resonance Angiography Magnetic Resonance Imaging Male Neurology Radiography Rats Rats, Sprague-Dawley subarachnoid hemorrhage Subarachnoid Hemorrhage - pathology Subarachnoid Hemorrhage - physiopathology Time Factors Vasoconstriction
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Beschreibung
Zusammenfassung:	Highlights • Subarachnoid hemorrhage (SAH) results in transient vasospasm and venous abnormality. • SAH transiently reduces basal cerebral blood flow and its response to hypercapnia. • SAH causes transient diffusion change but no ischemic brain injury. • Both SAH and control rats show reduced open-field activities. • There are however no differences in functional deficits between groups.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.12.027